Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 161
interventional 124
Observational 32
Registry 5

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 73
Drug|Other 11
Drug|Procedure 10
Procedure 8
Device 6
Biological|Drug 4
Other 3
Drug|placebo 2
Biological 1
Biological|Other 1
Biological|Radiation 1
Device|Drug 1
Device|Other 1
Drug|placebo|Procedure 1
Other|placebo 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 53
NA 10
Korea, Republic of 7
Austria 6
Germany 4
Japan 4
Brazil 3
China 3
France 3
Belgium 2
Canada 2
Australia|Austria|France|Germany|Hungary|Italy|Japan|Korea, Republic of|Latvia|Singapore 1
Australia|Canada|Czech Republic|Denmark|France|Greece|Hungary|Ireland|Italy|Netherlands|Poland|Portugal|Slovakia|Spain|Sweden|Switzerland|United Kingdom 1
Australia|Canada|Denmark|France|Germany|Italy|Spain|United Kingdom 1
Austria|Australia|Canada|Czech Republic|Denmark|Greece|Hungary|Ireland|Italy|Netherlands|Poland|Portugal|Slovakia|Spain|Sweden|Switzerland|Turkey|United Kingdom 1
Chile 1
China|Hong Kong|India|Indonesia|Philippines|Taiwan|Vietnam 1
China|Hong Kong|Indonesia|Philippines|Taiwan|Vietnam 1
Czech Republic|Germany|Hungary|Poland|United Kingdom 1
Denmark 1
Egypt 1
France|Germany|Israel|Italy|Spain|United Kingdom 1
Germany|Hungary|Poland|United Kingdom 1
Iran, Islamic Republic of 1
Italy 1
Japan|Korea, Republic of 1
Lebanon 1
Norway 1
Spain 1
Sweden 1
Taiwan 1
United States|Australia|Austria|Canada|Czechia|France|Germany|Israel|Mexico|Philippines|Portugal|South Africa|Taiwan 1
United States|Australia|Canada|Israel|South Africa 1
United States|Austria|Canada|China|Denmark|France|Germany|Hong Kong|Israel|Italy|Japan|Puerto Rico|Russian Federation|Slovakia|Spain|Switzerland|Taiwan|United Kingdom 1
United States|Brazil|Canada|Colombia|Hong Kong|India|Italy|Korea, Republic of|New Zealand|Poland|Singapore|Spain|United Kingdom 1
United States|Canada|Colombia|India|Israel 1
United States|Canada|Japan 1
United States|Puerto Rico 1

Sites per Study

Site_count Study_Count
1 73
2 6
3 3
4 7
5 2
6 5
7 3
8 1
10 1
11 1
12 1
13 4
14 1
20 1
33 1
34 1
35 1
37 1
42 2
56 1
61 1
64 1
66 1
72 1
73 1
78 1
82 1
100 1

Phase

Phase Study_Count
Phase 3 30
N/A 24
Phase 4 23
Phase 1/Phase 2 14
Phase 2 14
Phase 1 13
Phase 2/Phase 3 5
Early Phase 1 1

Number of Arms

Number_of_Arms Count_of_Studies
1 40
2 53
3 14
4 2
6 1
8 2
12 1
NA 11

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 30 16.0000 1.00000 6.00000 12.00 40.0 10.0000 20.00000
1st Qu. 30 30.0000 4.00000 14.00000 20.25 51.5 60.0000 30.00000
Median 30 53.5000 20.00000 24.00000 31.00 63.0 243.0000 59.00000
Mean 30 101.4583 30.84615 37.23077 59.50 57.0 282.6552 89.65217
3rd Qu. 30 85.0000 28.00000 55.00000 58.00 65.5 392.0000 156.00000
Max. 30 608.0000 121.00000 121.00000 315.00 68.0 1260.0000 307.00000

Trial Group Type

group_type Group_Count
Experimental 116
Active Comparator 77
Sham Comparator 23
NA 11
Other 9
Placebo Comparator 4
No Intervention 1

Intervention Model

intervention_model Study_Count
Parallel Assignment 69
Single Group Assignment 47
NA 5
Crossover Assignment 3

Primary Purpose

primary_purpose Study_Count
Treatment 111
Other 7
Basic Science 3
Diagnostic 1
Supportive Care 1
NA 1

Observational Studies

Studies by Country

Country Study_Count
United States 10
Belgium 2
China 2
France 2
Japan 2
Korea, Republic of 2
NA 2
Argentina|Australia|Austria|Belgium|Brazil|Canada|Chile|China|Colombia|Costa Rica|Czech Republic|Dominican Republic|Ecuador|Egypt|France|Germany|Greece|Guatemala|Hong Kong|Hungary|India|Ireland|Israel|Italy|Japan|Korea, Republic of|Malaysia|Mexico|Netherlands|Panama|Peru|Poland|Portugal|Russian Federation|Saudi Arabia|Singapore|Slovakia|Slovenia|Spain|Turkey|Ukraine|United Kingdom|Venezuela 1
Austria|Czechia|Denmark|Germany|Iceland|Switzerland|United Kingdom 1
Canada 1
China|Egypt|France|Germany|Italy|Kuwait|Lebanon|Russian Federation|Saudi Arabia|Taiwan|United Arab Emirates 1
Denmark 1
Denmark|Norway|Sweden 1
France|Germany|Spain|United Kingdom 1
Germany 1
Poland 1
Sweden 1

Sites per Study

Site_count Study_Count
1 25
3 2
4 2
8 1
11 1
463 1

Enrollment Metrics

Measure Observational
Min 1.000
1st Qu 31.500
Median 99.500
Mean 1282.781
3rd Qu 377.500
Max 30490.000

Observation Model

observational_model Study_Count
Cohort 19
Case-Only 6
Case-Control 2
Other 2
Case Control 1
Ecologic or Community 1
NA 1

Time Perspective

time_perspective Study_Count
Prospective 23
Retrospective 8
Cross-Sectional 1

Registries

Studies by Country

Country Study_Count
France 2
Italy 2
Germany 1

Sites per Study

Site_count Study_Count
1 3
3 1
9 1

Enrollment Metrics

Measure Registries
Min 50
1st Qu 100
Median 100
Mean 450
3rd Qu 1000
Max 1000

Registry Model

observational_model Study_Count
Cohort 4
Case-Only 1

Time Perspective

time_perspective Study_Count
Prospective 5

Follow-up

target_duration Study_Count
12 Months 2
2 Years 1
24 Months 1
5 Years 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT03405376 Prospective Trial of Treat and Extend Aflibercept for Macular Edema Secondary to Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT03405376 Recruiting Yeungnam University College of Medicine 2019-03-31
NCT03417401 Surgical Stabilizer Assisted RVC With rtPA for CRVO https://ClinicalTrials.gov/show/NCT03417401 Completed Universitaire Ziekenhuizen Leuven 2017-04-13
NCT03223714 Conbercept Ophthalmic Injection for Patients of Central Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT03223714 Recruiting Chengdu Kanghong Biotech Co., Ltd. 2019-12-31
NCT03108352 Conbercept Ophthalmic Injection for Patients With Macular Edema Caused by Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT03108352 Recruiting Chengdu Kanghong Biotech Co., Ltd. 2019-12-31
NCT03093701 TLC399 (ProDex) in Subjects With Macular Edema Due to Retinal Vein Occlusion (RVO) https://ClinicalTrials.gov/show/NCT03093701 Active, not recruiting Taiwan Liposome Company 2020-12-31
NCT03056092 Cytokine and Visual Outcome Variations in Eyes Receiving Ranibizumab https://ClinicalTrials.gov/show/NCT03056092 Recruiting St. Michael’s Hospital, Toronto 2020-02-28
NCT03056079 Cytokine and Visual Outcome Variations in Eyes Receiving Aflibercept https://ClinicalTrials.gov/show/NCT03056079 Recruiting St. Michael’s Hospital, Toronto 2020-02-28
NCT03038048 30g vs 33g Needle for Intravitreal Injections https://ClinicalTrials.gov/show/NCT03038048 Completed Wills Eye 2017-04-27
NCT02953938 Study to Show a Superior Benefit in Terms of Reduction of Ranibizumab Injections in Patients Receiving Ranibizumab Plus Laser Photocoagulation Combination Therapy Without Loss of Efficacy and Safety https://ClinicalTrials.gov/show/NCT02953938 Completed Novartis 2018-12-28
NCT02898480 Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning https://ClinicalTrials.gov/show/NCT02898480 Completed University of Aarhus 2016-11-14
NCT02867735 A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Activity of Intravitreal LKA651 in Patients With Macular Edema https://ClinicalTrials.gov/show/NCT02867735 Completed Novartis 2018-02-15
NCT02747030 Phase I RVC With Ocriplasmin for CRVO https://ClinicalTrials.gov/show/NCT02747030 Completed Universitaire Ziekenhuizen Leuven 2017-08-10
NCT02698566 A Study in Patients With Neovascular Age Related Macular Degeneration or Macular Edema Secondary To Retinal Vein Occlusion to Evaluate Usability of the Ranibizumab (Lucentis®) Prefilled Syringe (PFS) https://ClinicalTrials.gov/show/NCT02698566 Completed Genentech, Inc. 2016-04-05
NCT02614937 Study of Squalamine Lactate for the Treatment of Macular Edema Related to Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT02614937 Completed Ohr Pharmaceutical Inc. 2014-12-31
NCT02800642 Evaluation of a Treat and Extend Regimen of Intravitreal Aflibercept for Macular Edema Secondary to CRVO https://ClinicalTrials.gov/show/NCT02800642 Completed Bayer 2019-07-31
NCT02571972 Dorzolamide-timolol Drops With Injections to Treat AMD, RVO or DME. https://ClinicalTrials.gov/show/NCT02571972 Completed Wills Eye 2015-09-30
NCT02556723 Intravitreal Injections of Ziv-aflibercept for Macular Diseases https://ClinicalTrials.gov/show/NCT02556723 Completed Retina Clinic, Sao Paulo, Brazil 2015-09-30
NCT02033031 Long-term Treatment Effect of Intravitreal Ant-VEGF in Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT02033031 Completed Medical University of Vienna 2012-11-30
NCT02521116 Comparison of Retinal Oxygenation and Retinal Vessel Diameters in Healthy Subjects and Patients With Diabetic Retinopathy or Retinal Vein Occlusion Between DVA and Oxymap https://ClinicalTrials.gov/show/NCT02521116 Completed Medical University of Vienna 2017-01-03
NCT02510885 SD-OCT Angiography https://ClinicalTrials.gov/show/NCT02510885 Recruiting Duke University 2020-05-31
NCT02503540 Peripheral and Macular Retinal Vascular Perfusion and Leakage in DME and RVO https://ClinicalTrials.gov/show/NCT02503540 Completed The Cleveland Clinic 2018-02-06
NCT02478515 Evaluation of the Usefulness of a PRN Regimen Using Ranibizumab for Macular Edema Due to Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT02478515 Completed Nagoya City University 2019-03-31
NCT02387788 Open Label Study to Assess the Efficacy and Safety of AKB-9778 in Subjects With Macular Edema Due to RVO https://ClinicalTrials.gov/show/NCT02387788 Completed Aerpio Therapeutics 2017-04-30
NCT02303184 Suprachoroidal Injection of Triamcinolone Acetonide With IVT Aflibercept in Subjects With Macular Edema Following RVO https://ClinicalTrials.gov/show/NCT02303184 Completed Clearside Biomedical, Inc. 2016-03-31
NCT02245516 Exploratory Study of KPI-121 Effect on Intra- or Subretinal Fluid Due to Retinal Vein Occlusion/Diabetic Macular Edema https://ClinicalTrials.gov/show/NCT02245516 Completed Kala Pharmaceuticals, Inc. 2014-12-31
NCT02144662 Prognostic Factors for Visual Improvement in Patients Undergoing Intravitreal Ranibizumab for Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT02144662 Completed St. Marianna University School of Medicine 2017-01-31
NCT02140411 Efficacy and Safety of Lucentis® (Ranibizumab Intravitreal Injections) in Chilean Patients With Diabetic Macular Edema. https://ClinicalTrials.gov/show/NCT02140411 Completed Novartis 2016-12-21
NCT02118831 Systemic Pharmacokinetics Following Intravitreal Injections of Anti-VEGF https://ClinicalTrials.gov/show/NCT02118831 Completed California Retina Consultants 2014-02-28
NCT01295112 Effect of Ozurdex® 0.7 mg on Improvement of Efficacy of Bevacizumab for Central Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01295112 Completed Texas Retina Associates 2015-10-31
NCT01277302 A Study Evaluating Dosing Regimens for Treatment With Intravitreal Ranibizumab Injections in Subjects With Macular Edema Following Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01277302 Completed Genentech, Inc. 2012-10-31
NCT02006147 Phase 1 Open-label Study to Evaluate Efficacy and Tolerability of TLC399 in Patients With Macular Edema Due to RVO https://ClinicalTrials.gov/show/NCT02006147 Active, not recruiting Taiwan Liposome Company 2020-12-31
NCT01976338 Ranibizumab Intravitreal Injections Versus Sham Control in Patients With Branch Retinal Vein Occlusion (BRVO) https://ClinicalTrials.gov/show/NCT01976338 Completed Novartis 2016-03-28
NCT01976312 Ranibizumab Intravitreal Injections Versus Sham Control in Patients With Central Retinal Vein Occlusion (CRVO) https://ClinicalTrials.gov/show/NCT01976312 Completed Novartis 2016-03-14
NCT01975103 Non-damaging Retinal Laser Therapy With PASCAL Laser for Macular Diseases https://ClinicalTrials.gov/show/NCT01975103 Recruiting Federal University of Rio Grande do Sul 2020-04-30
NCT01969708 Study of Comparative Treatments for Retinal Vein Occlusion 2 (SCORE2) https://ClinicalTrials.gov/show/NCT01969708 Active, not recruiting The Emmes Company, LLC 2016-11-30
NCT01903720 A Safety and Efficacy Study of OZURDEX® in Macular Edema Associated With Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01903720 Completed Allergan 2014-09-24
NCT01870427 NEWTON: Aflibercept Injection for Previously Treated Macular Edema Associated With Central Retinal Vein Occlusions https://ClinicalTrials.gov/show/NCT01870427 Completed Northern California Retina Vitreous Associates 2015-08-31
NCT01790685 Ozurdex for Retinal Vein Occlusion Study (ORVO Study) https://ClinicalTrials.gov/show/NCT01790685 Completed Johns Hopkins University 2014-12-31
NCT01789437 Diameters and Wall-to-lumen Ratio of Retinal Arterioles in Patients With Retinal Vein Occlusion. https://ClinicalTrials.gov/show/NCT01789437 Completed Università degli Studi di Brescia 2012-06-30
NCT01767545 Dexamethasone-implant for the Treatment of RVO https://ClinicalTrials.gov/show/NCT01767545 Completed Ludwig-Maximilians - University of Munich 2011-01-31
NCT01746615 Assessment of Retinal Vessel Diameters and Red Blood Velocities in Patients With BRVO and Healthy Subjects https://ClinicalTrials.gov/show/NCT01746615 Recruiting Medical University of Vienna 2020-01-31
NCT01724554 Impact of Intravitreal Aflibercept Injections on Capillary Non-Perfusion https://ClinicalTrials.gov/show/NCT01724554 Completed Ophthalmic Consultants of Boston 2014-10-31
NCT01710839 Widefield Angiography Guided Targeted-retinal Photocoagulation Combined With Anti VEgf Intravitreal Injections for the Treatment of Ischemic Central Retinal Vein Occlusion, Hemi Retinal Vein Occlusion, and Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01710839 Completed Greater Houston Retina Research 2015-10-31
NCT01662518 DDS-25 Gauge in Patients With Macular Edema Secondary to Retinal Vein Occlusion (RVO) https://ClinicalTrials.gov/show/NCT01662518 Completed Centro de Pesquisa Rubens Siqueira 2016-01-31
NCT01640171 Anesthesia Preference for Intravitreal Injection: Topical or Subconjunctival https://ClinicalTrials.gov/show/NCT01640171 Completed Retina Vitreous Associates of Florida 2013-09-30
NCT01614509 Combined Therapy of Posterior Subtenon Triamcinolone Acetonide and Intravitreal Bevacizumab for Macular Edema Secondary to Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01614509 Completed Yeungnam University College of Medicine 2012-08-31
NCT01599650 Efficacy and Safety of Ranibizumab With or Without Laser in Comparison to Laser in Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01599650 Completed Novartis 2015-05-31
NCT01581411 Intra-arterial Thrombolysis for Severe Recent Central Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01581411 Completed Weill Medical College of Cornell University 2015-11-30
NCT01580020 Extension Study to Compare Long-term Efficacy and Safety of Ranibizumab Intravitreal Injections Versus Dexamethasone Intravitreal Implant in Patients With RVO https://ClinicalTrials.gov/show/NCT01580020 Completed Novartis 2014-10-31
NCT01535261 Ranibizumab Intravitreal Injections in Patients With Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01535261 Completed Novartis 2015-03-31
NCT01521559 Study to Assess the Clinical Efficacy and Safety of Intravitreal Aflibercept Injection (IAI;EYLEA®;BAY86-5321) in Patients With Branch Retinal Vein Occlusion (BRVO) https://ClinicalTrials.gov/show/NCT01521559 Completed Regeneron Pharmaceuticals 2013-08-31
NCT01512901 Efficacy and Safety of Betamethasone Microsphere in Patients With Macular Edema Following Branch Retinal Vein Occlusion (HIKARI) https://ClinicalTrials.gov/show/NCT01512901 Completed Santen Pharmaceutical Co., Ltd. NA
NCT01471691 Intravitreal Ranibizumab 0.5MG, or 1.0mg for RVO With Macular Edema Previously Receiving Bevacizumab https://ClinicalTrials.gov/show/NCT01471691 Completed Hanscom, Thomas, M.D. 2014-02-28
NCT01468844 Minocycline to Treat Central Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01468844 Completed National Institutes of Health Clinical Center (CC) 2020-02-01
NCT01468831 Minocycline to Treat Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01468831 Completed National Institutes of Health Clinical Center (CC) 2020-02-20
NCT01449682 Efficacy of an Intravitreal DEX Implant in Retinal Vein Occlusion Following Treatment With Anti-VEGF Injections. https://ClinicalTrials.gov/show/NCT01449682 Completed Retina Macula Institute 2012-07-31
NCT01448018 Hemodilution Versus Ranibizumab in Early-onset Central Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01448018 Completed Centre Hospitalier Intercommunal Creteil 2013-06-30
NCT01442064 An Extension Study to Evaluate Safety and Tolerability of Ranibizumab in Macular Edema Secondary to Retinal Vein Occlusion (Cohort 2) https://ClinicalTrials.gov/show/NCT01442064 Completed Genentech, Inc. 2010-07-31
NCT01428388 Bevacizumab Versus Ranibizumab in Treatment of Macular Edema From Vein Occlusion https://ClinicalTrials.gov/show/NCT01428388 Completed Barnes Retina Institute 2015-10-31
NCT01427751 Safety and Efficacy Study of Ozurdex® Compared to Lucentis® in Patients With Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01427751 Completed Allergan 2014-11-04
NCT01396083 Efficacy and Safety of Ranibizumab Intravitreal Injections Versus Dexamethasone Intravitreal Implant in Patients With Central Retinal Vein Occlusion (CRVO) https://ClinicalTrials.gov/show/NCT01396083 Completed Novartis 2014-01-31
NCT01396057 Efficacy and Safety of Ranibizumab Intravitreal Injections Versus Dexamethasone Intravitreal Implant in Patients With Branch Retinal Vein Occlusion (BRVO) https://ClinicalTrials.gov/show/NCT01396057 Completed Novartis 2013-06-30
NCT01377597 Efficacy and Safety of Ranibizumab in Japanese Patients With Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01377597 Completed Novartis 2012-04-30
NCT04290195 Use of Ziv Aflibercept in Different Retinal Diseases https://ClinicalTrials.gov/show/NCT04290195 Completed Tanta University 2019-12-01
NCT04142164 Computer-based Tutorial and Automated Speech Recognition for Intravitreal Drug Injections https://ClinicalTrials.gov/show/NCT04142164 Recruiting Vienna Institute for Research in Ocular Surgery 2021-01-01
NCT04120636 Phase I Study of Episcleral Celecoxib for Treatment of Macular Edema and Inflammatory Disorders of the Posterior Pole https://ClinicalTrials.gov/show/NCT04120636 Recruiting Targeted Therapy Technologies, LLC 2020-10-30
NCT04120311 Episcleral Dexamethasone for Treatment of Macular Edema and Inflammatory Disorders of the Posterior Pole https://ClinicalTrials.gov/show/NCT04120311 Recruiting Targeted Therapy Technologies, LLC 2020-08-25
NCT04085341 A Depot Formulation of Sunitinib Malate (GB-102) in Subjects With Diabetic Macular Edema and Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT04085341 Active, not recruiting Graybug Vision 2020-04-30
NCT03981549 Treatment of Central Retinal Vein Occlusion Using Stem Cells Study https://ClinicalTrials.gov/show/NCT03981549 Recruiting The Emmes Company, LLC 2022-12-31
NCT03918590 Post Intravitreal Injection Topical NSAID vs. Patching https://ClinicalTrials.gov/show/NCT03918590 Enrolling by invitation The New York Eye & Ear Infirmary 2019-05-01
NCT03908307 Evaluation of OZURDEX® in Patients With Macular Edema Secondary to Retinal Vein Occlusion in China https://ClinicalTrials.gov/show/NCT03908307 Recruiting Allergan 2021-09-30
NCT03892434 Bevacizumab Versus DEX Implant Followed by Bevacizumab in ME Secondary to BRVO https://ClinicalTrials.gov/show/NCT03892434 Recruiting Yeungnam University College of Medicine 2019-12-18
NCT03802630 Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Patients With Visual Impairment Due to Macular Edema Secondary to Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT03802630 Recruiting Novartis 2023-05-26
NCT03739593 Study Assessing AR-1105 in Subjects With Macular Edema Due to Retinal Vein Occlusion (RVO) https://ClinicalTrials.gov/show/NCT03739593 Active, not recruiting Aerie Pharmaceuticals 2020-05-31
NCT03680794 Soluble Cluster of Differentiation 160 (sCD160) in Sera and Intra-ocular Fluids: Association With Ischaemic Retinopathies https://ClinicalTrials.gov/show/NCT03680794 Recruiting CHU de Reims 2021-12-01
NCT03651011 Navigated Laser In Branch Retinal Vein Occlusion Study https://ClinicalTrials.gov/show/NCT03651011 Recruiting Odense University Hospital 2020-08-10
NCT03525132 Study of the Retinal Vascularization by Laser Doppler Velocimetry Coupled With an Adaptive Optics Camera ( AO-LDV) https://ClinicalTrials.gov/show/NCT03525132 Recruiting University Hospital, Grenoble 2020-03-18
NCT01247220 REtinal Vein OccLUsion Treatment With Scatter Laser Guided by UWFA in combiNAtion With Ranibizumab Study https://ClinicalTrials.gov/show/NCT01247220 Completed Retina Associates of Florida, P.A. 2014-05-31
NCT01231633 Comparison of Initial Ozurdex (Dexamethasone Implant) to Avastin (Bevacizumab) for Treatment of Macular Edema Caused by Central Retinal Vein Occlusion (CRVO) https://ClinicalTrials.gov/show/NCT01231633 Completed Long Island Vitreoretinal Consultants 2014-09-30
NCT01198327 Extended Follow-up of Patients With Macular Edema Due to Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01198327 Completed Johns Hopkins University 2012-12-31
NCT01085734 Single Site, Masked, Randomized, Controlled Study to Assess Efficacy of Osurdex as Adjunct to Avastin Compared With Avastin Alone in the Treatment of Patients With Macular Edema Due to Central or Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01085734 Completed Maturi, Raj K., M.D., P.C. 2011-10-31
NCT01053858 Triamcinolone or Bevacizumab for Central Retinal Vein Occlusion With Poor Vision https://ClinicalTrials.gov/show/NCT01053858 Completed Hallym University Medical Center 2009-01-31
NCT01028248 Lucentis for Macular Edema Associated With Central Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01028248 Completed California Retina Consultants 2012-06-30
NCT01027650 Safety and Efficacy of AGN208397 in the Treatment of Macular Edema Associated With Retinal Vein Occlusion (RVO) https://ClinicalTrials.gov/show/NCT01027650 Completed Allergan 2012-04-30
NCT01027481 Ranibizumab in Patients With Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01027481 Completed Medical University of Vienna 2009-11-30
NCT01012973 Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (CRVO) https://ClinicalTrials.gov/show/NCT01012973 Completed Bayer 2011-02-28
NCT01003106 Ranibizumab DosE Comparison and the Role of LAser in REtinal Vein Occlusions https://ClinicalTrials.gov/show/NCT01003106 Completed Johns Hopkins University 2015-04-30
NCT00970957 Safety and Effectiveness of Bevacizumab Intravitreal Injections in the Treatment of Macular Edema Secondary to Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT00970957 Completed Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA 2013-02-28
NCT00952614 A Study of a Sustained Release Fluocinolone Implant for Treatment of Central Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT00952614 Completed Duke University 2009-05-31
NCT00943072 Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (CRVO) https://ClinicalTrials.gov/show/NCT00943072 Completed Regeneron Pharmaceuticals 2010-10-31
NCT00942864 Effect of Intravitreal Ranibizumab Injection With Retinal Vein Occlusion (RVO) https://ClinicalTrials.gov/show/NCT00942864 Completed Novartis 2009-12-31
NCT00906685 Bevacizumab for Central Retinal Vein Occlusion Study https://ClinicalTrials.gov/show/NCT00906685 Completed St. Erik Eye Hospital 2011-03-31
NCT00831350 Posterior Vitreous Detachment (PVD) Assessment During Dual Retinal Vein Occlusion (RVO) Lucentis Evaluations https://ClinicalTrials.gov/show/NCT00831350 Completed Barnes Retina Institute 2011-07-31
NCT01968239 Proof of Concept Study of Re-treatment in BRVO With Ranibizumab Guided by OCT https://ClinicalTrials.gov/show/NCT01968239 Completed University of Leipzig 2016-06-17
NCT00805064 Combined Triple Procedure in Retinal Vein Occlusion (RVO) https://ClinicalTrials.gov/show/NCT00805064 Completed Johann Wolfgang Goethe University Hospital 2007-12-31
NCT00804102 Transcorneal Electrical Stimulation Therapy for Retinal Disease https://ClinicalTrials.gov/show/NCT00804102 Completed Okuvision GmbH 2011-04-30
NCT02486484 Ziv-aflibercept in Ocular Disease Requiring Anti-VEGF Injection https://ClinicalTrials.gov/show/NCT02486484 Recruiting Rafic Hariri University Hospital 2019-05-31
NCT03790852 Exploratory Study to Investigate the Bioactivity, Ocular and Systemic Safety, Tolerability, and Pharmacokinetics Following Single and Multiple Intravitreal Administrations of KSI-301 in Subjects With wAMD, DME and RVO https://ClinicalTrials.gov/show/NCT03790852 Active, not recruiting Kodiak Sciences Inc 2021-06-30
NCT02390245 Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study https://ClinicalTrials.gov/show/NCT02390245 Active, not recruiting Wills Eye 2019-09-30
NCT01573572 Continuation of Previous Study to Gather More Data on Effect of Macugen on the Corneal Endothelium https://ClinicalTrials.gov/show/NCT01573572 Completed Bausch Health Americas, Inc. 2019-11-04
NCT00636493 Fluocinolone Acetonide Implant for Retinal Vein Occlusion (RVO) https://ClinicalTrials.gov/show/NCT00636493 Completed Duke University 2009-05-31
NCT00612261 Sheathotomy vs. Intravitreal Triamcinolone for Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT00612261 Completed Yonsei University 2007-08-31
NCT00567697 A Randomized Study Comparing Ranibizumab to Sham in Patients With Macular Edema Secondary to CRVO https://ClinicalTrials.gov/show/NCT00567697 Completed Aleris Helse 2008-10-31
NCT00562406 Ranibizumab for Branch Retinal Vein Occlusion Associated Macular Edema Study (RABAMES) https://ClinicalTrials.gov/show/NCT00562406 Completed Klinikum Ludwigshafen 2010-09-30
NCT00532142 The ROVO Study: Radial Optic Neurotomy for CVO https://ClinicalTrials.gov/show/NCT00532142 Completed Rudolf Foundation Clinic NA
NCT00493064 To Study the Effectiveness and Safety of Niacin and a Topical Steroid Eye Drop to Treat Retinal Vein Occlusions https://ClinicalTrials.gov/show/NCT00493064 Completed Palo Alto Medical Foundation 2016-10-31
NCT00486018 A Study of the Efficacy and Safety of Ranibizumab Injection in Patients With Macular Edema Secondary to Branch Retinal Vein Occlusion (BRAVO) https://ClinicalTrials.gov/show/NCT00486018 Completed Genentech, Inc. 2009-05-31
NCT00485836 A Study of the Efficacy and Safety of Ranibizumab Injection in Patients With Macular Edema Secondary to Central Retinal Vein Occlusion (CRUISE) https://ClinicalTrials.gov/show/NCT00485836 Completed Genentech, Inc. 2009-06-30
NCT00407355 Ranibizumab (Lucentis) for Macular Edema Secondary to Vein Occlusions https://ClinicalTrials.gov/show/NCT00407355 Completed Johns Hopkins University 2013-02-28
NCT00406796 Lucentis for Central Retinal Vein Occlusion (CRVO) https://ClinicalTrials.gov/show/NCT00406796 Completed California Retina Consultants 2008-09-30
NCT00406471 Rubeosis Anti-VEGF (RAVE) Trial for Ischemic Central Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT00406471 Completed Greater Houston Retina Research 2011-01-31
NCT00406107 Evaluation of Macugen Treatment of Macular Edema Due to Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT00406107 Completed Palmetto Retina Center, LLC 2007-12-31
NCT00403039 Intravitreal Ranibizumab Treatment of Central Retinal Vein Occlusion With Macular Edema https://ClinicalTrials.gov/show/NCT00403039 Completed Vitreous -Retina- Macula Consultants of New York 2011-12-31
NCT00370266 Intravitreal Triamcinolone for Acute Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT00370266 Completed Shahid Beheshti University of Medical Sciences 2007-10-31
NCT00308477 A Study of the Safety and Efficacy of a New Treatment for Macular Edema Resulting From Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT00308477 Completed Sanwa Kagaku Kenkyusho Co., Ltd. NA
NCT00168324 A Study of the Safety and Efficacy of a New Treatment for Macular Edema Resulting From Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT00168324 Completed Allergan 2008-03-01
NCT00168298 A Study of the Safety and Efficacy of a New Treatment for Macular Edema Resulting From Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT00168298 Completed Allergan 2008-03-01
NCT00106132 Steroid Injections vs. Standard Treatment for Macular Edema Due to Retinal Blood Vessel Blockage https://ClinicalTrials.gov/show/NCT00106132 Completed National Institutes of Health Clinical Center (CC) NA
NCT00105027 The Standard Care vs. COrticosteroid for REtinal Vein Occlusion (SCORE) Study https://ClinicalTrials.gov/show/NCT00105027 Completed The Emmes Company, LLC 2009-02-28
NCT00101764 Intravitreal v. Sub-tenon Injections of Triamcinolone Acetonide for Macular Edema in Retinal Disorders https://ClinicalTrials.gov/show/NCT00101764 Completed National Institutes of Health Clinical Center (CC) NA
NCT00088283 Pegaptanib Sodium Compared to Sham Injection in Patients With Recent Vision Loss Due to Macular Edema Secondary to Central Retinal Vein Occlusion (CRVO) https://ClinicalTrials.gov/show/NCT00088283 Completed Eyetech Pharmaceuticals NA
NCT00071227 Eye Injections of Triamcinolone Acetonide for Retinal Blood Vessel Disorders https://ClinicalTrials.gov/show/NCT00071227 Completed National Institutes of Health Clinical Center (CC) NA
NCT00035906 Research Study in Patients With Persistent Macular Edema https://ClinicalTrials.gov/show/NCT00035906 Completed Allergan 2004-08-31
NCT00000131 Central Vein Occlusion Study (CVOS) https://ClinicalTrials.gov/show/NCT00000131 Completed National Eye Institute (NEI) NA

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT02956330 Retrospective Study of the Safety and Efficacy of Patients With RVO in Subjects Who Completed Parent Study CLS1003-201 https://ClinicalTrials.gov/show/NCT02956330 Completed Clearside Biomedical, Inc. 2017-04-12
NCT02645747 Retrospective Data Analysis of Patients Treated for Macular Edema Due to Central Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT02645747 Completed Bayer 2017-12-23
NCT02585401 Evaluation of Physician Knowledge of Safety and Safe Use Information for Aflibercept in Canada https://ClinicalTrials.gov/show/NCT02585401 Completed Bayer 2016-03-31
NCT02523339 Study of Retinal Oxygenation in Central Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT02523339 Active, not recruiting University of Iceland 2018-06-30
NCT02215109 Retinal Vessel Diameter in Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT02215109 Completed Kyungpook National University Hospital 2016-07-31
NCT02181530 Retrospective Data Collection Study in Patients With Macular Oedema Receiving OZURDEX® https://ClinicalTrials.gov/show/NCT02181530 Completed Allergan 2014-10-31
NCT02126423 Resistance to Antibiotics in Patients Receiving Eye Injections https://ClinicalTrials.gov/show/NCT02126423 Completed Prism Vision Group 2014-09-30
NCT01282411 Anatomic Outcomes Following Ozurdex Injections https://ClinicalTrials.gov/show/NCT01282411 Completed Barnes Retina Institute 2011-05-31
NCT02040220 Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Eylea for Central Retinal Vein Occlusion (CRVO) https://ClinicalTrials.gov/show/NCT02040220 Completed Bayer 2018-06-01
NCT01318941 Observe the Effectiveness and Safety of Ranibizumab in Real Life Setting https://ClinicalTrials.gov/show/NCT01318941 Completed Novartis 2016-04-30
NCT01976650 Safety and Efficacy of Dexamethasone (OZURDEX®) Intravitreal Implant in Korea https://ClinicalTrials.gov/show/NCT01976650 Completed Allergan 2015-03-31
NCT01918371 A Retrospective Study of Anti-Vascular Endothelial Growth Factor (VEGF) Injections for Retinal Vein Occlusion or Diabetic Macular Edema https://ClinicalTrials.gov/show/NCT01918371 Completed Allergan 2014-09-04
NCT01875770 Continuing Assessment of Patients Treated With ranibizUmab for REtinal Vein Occlusion (CAPTURE) https://ClinicalTrials.gov/show/NCT01875770 Active, not recruiting Johns Hopkins University 2021-12-31
NCT01793181 Vitamin D Levels in Patients With Central Retinal Vein Occlusion- a Prospective Controlled Study https://ClinicalTrials.gov/show/NCT01793181 Completed St. Erik Eye Hospital 2014-08-31
NCT01692938 Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO https://ClinicalTrials.gov/show/NCT01692938 Completed Optos, PLC 2012-11-30
NCT01618266 Study of Ozurdex® Treatment Practice in Patients With Macular Oedema Due to Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01618266 Completed Allergan 2013-04-30
NCT01571557 A Safety and Efficacy Study to Assess OZURDEX® in Patients With Macular Oedema Secondary to Retinal Vein Occlusion (RVO) https://ClinicalTrials.gov/show/NCT01571557 Completed Allergan 2014-03-31
NCT01568021 Post Market Surveillance of OZURDEX® for Branch Retinal Vein Occlusion (BRVO) and Central Retinal Vein Occlusion (CRVO) https://ClinicalTrials.gov/show/NCT01568021 Completed Allergan 2013-11-30
NCT01566526 Retrospective Data Collection Study in Patients Receiving Two or More OZURDEX® Injections for Macular Oedema Secondary to Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT01566526 Completed Allergan 2012-06-30
NCT01539577 A Long-Term Safety Study of OZURDEX® in Clinical Practice https://ClinicalTrials.gov/show/NCT01539577 Completed Allergan 2016-03-31
NCT01411696 Retrospective Study in Patients Receiving Two or More OZURDEX® Injections for Retinal Vein Occlusion (RVO) https://ClinicalTrials.gov/show/NCT01411696 Completed Allergan 2012-03-31
NCT01360385 Retinal Ischemia in Central Retinal Vein Occlusion, and the Effects of Treatment With Intravitreal Ranibizumab https://ClinicalTrials.gov/show/NCT01360385 Completed Glostrup University Hospital, Copenhagen 2012-07-31
NCT04395859 Collateral Damage From the COVID-19 Pandemic Observed in Patients Treated With Intravitreal Injections (IVT) of Anti-angiogenic Agents https://ClinicalTrials.gov/show/NCT04395859 Recruiting Fondation Ophtalmologique Adolphe de Rothschild 2021-12-31
NCT04140448 Ultra-wide-field Fluorescein Angiography in Patients With Macular Edema Secondary to Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT04140448 Recruiting Renmin Hospital of Wuhan University 2021-10-30
NCT03753893 Ocular Manifestations in Rheumatic Diseases https://ClinicalTrials.gov/show/NCT03753893 Active, not recruiting Lawson Health Research Institute 2020-10-01
NCT03559491 Dexamethasone Intravitreal Implant in Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT03559491 Completed Università degli Studi dell’Insubria 2017-10-01
NCT01992575 OCT in Retinal Vein Occlusions https://ClinicalTrials.gov/show/NCT01992575 Active, not recruiting Oregon Health and Science University 2021-12-31
NCT01496625 National Eye Institute Biorepository for Retinal Diseases https://ClinicalTrials.gov/show/NCT01496625 Recruiting National Institutes of Health Clinical Center (CC) NA
NCT04075695 Ultra-wide-field Fluorescein Angiography in Patients With Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT04075695 Recruiting Renmin Hospital of Wuhan University 2020-08-12
NCT03161912 A Study to Evaluate the Effectiveness of Intravitreal Aflibercept in Patients With Diabetic Macular Edema and/or Macular Edema Secondary to Retinal Vein Occlusion, Which Either Have or Have Not Been Pretreated for Their Disease https://ClinicalTrials.gov/show/NCT03161912 Recruiting Bayer 2021-08-31
NCT00685490 Vitrectomy for Branch Retinal Vein Occlusion https://ClinicalTrials.gov/show/NCT00685490 Completed Shinjo Ophthalmologic Institute NA
NCT00556114 A Pilot Study of Functional Optical Coherence Tomography for Ocular Imaging https://ClinicalTrials.gov/show/NCT00556114 Completed University of California, Irvine 2013-07-31

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT02880644 Ultra-wide Fluorescein Angiography in Patients With Central Retinal Vein Occlusion Treated by Afilbercept https://ClinicalTrials.gov/show/NCT02880644 Recruiting Centre Hospitalier Intercommunal Creteil 2020-01-31
NCT02257333 Retinal Thrombosis and Atherosclerosis https://ClinicalTrials.gov/show/NCT02257333 Recruiting University of Roma La Sapienza 2019-09-30
NCT04128150 High Resolution Retina Imaging https://ClinicalTrials.gov/show/NCT04128150 Recruiting Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts 2023-01-30
NCT03778502 DOAC in Unusual Site Venous Thrombosis https://ClinicalTrials.gov/show/NCT03778502 Recruiting University of Malta 2022-12-31
NCT03762226 Influence of Systemic Parameters in Diabetic Macular Edema - LIPSIA Study https://ClinicalTrials.gov/show/NCT03762226 Recruiting University of Leipzig 2021-06-30